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Tuesday, November 26, 2013

Unintended Side Effects Of PrEP

Damon L. Jacobs checks in with My PrEP Experience after 855 doses of Truvada as PrEP (more than 2 years.) Read earlier posts from Damon about his PrEP experience on this blog.

But what about the side effects?

Beginning the use of Truvada as PrEP on July 19, 2011 was not without some reservation.

Sure, I knew it could offer me an opportunity to feel more in control of my body and my health. Sure, I knew it could enable me to experience sexual intimacy without fear of HIV for the first time in my life. And sure, I knew it could enhance my ability to educate about safer sex practices as a therapist and an activist.

But what about the side effects? The prospect of having damaged kidneys did not thrill me in the least. Plus bone density reduction? I didn’t even know what that was! Nausea, diarrhea, abdominal cramping? Those were not the kind of adventures I welcomed. What about all the unintended side effects that nobody could predict? How was I going to deal with all that?

I was relieved to find during my first few weeks of taking Truvada that I experienced no physical side effects whatsoever. But what about the problems I wouldn’t be able to detect? What about the harm to my vital organs that I may not be able to sense? Was protection from HIV worth the risk?

For this reason, my doctor began the pattern of seeing me regularly, and drawing blood consistently. During the first year of using PrEP he saw me every three months. Beginning the second year he expanded it to every four months. By doing this he’s been able to monitor all my liver enzymes, kidney levels, and a bunch of other stuff that I don’t fully understand.

On November 20, 2013, I met with my doctor for my routine checkup. I had my blood drawn a few weeks earlier. As usual, this process was done with some trepidation on my part. Have I been damaging myself by using this medication? Am I willingly depositing toxic chemicals in my system? Am I sabotaging my organs for sexual pleasure?

After two years and four months (or 855 doses), my kidneys are fine. My organs are great. As a matter of fact, at age 42, I’m in the best shape of my life. How is that even possible?

As it turns out, taking PrEP has not only been a regular commitment to my physical health, but it has also prompted me to take active self-care measures in other areas.

Feeling protected from HIV helps me to feel more affirmative sexually. Feeling affirmative sexually gives me more confidence and energy. More confidence and energy leads me to exercise consistently and eat healthier. Exercising more and eating healthier gives me more strength and confidence. Having strength and confidence promotes improved mood, happier relationships, and more satisfaction in my professional life, which all positively impacts my physical health.

So have there been unintended side effects of taking Truvada the last two years and four months?

You bet!

It unintentionally has had an affirmative and healthy impact in every other area of my life. It unexpectedly has given me a sense of efficacy, empowerment, and freedom that has benefited my physical, emotional, and sexual well being.

If those are the side effects, I’ll be looking forward to a whole lot more!


Damon L. Jacobs is a Licensed Marriage Family Therapist in New York City, who specializes working with individuals and couples in the GLBT community. He has spent 17 years treating issues related to HIV/AIDS, stress management, bullying trauma, grief/loss, social alienation, suicide management, care-taking fatigue, substance abuse, domestic violence, and anxiety disorders. He created and monitors the "PrEP Facts: Rethinking HIV and Sex" page on Facebook. He is also the author of the new book "Rational Relating: The Smart Way To Stay Sane In The Crazy World Of Love." Please contact at 



  1. As always, thank you so much for sharing your experience with PrEP, Damon. It is very helpful and affirming.

  2. I've been on Truvada (as PReP) for about the same time as you. I'm also in arguably the best shape of my life - except that I'm typing this comment with one hand because last week my left wrist shattered after a routine fall. I now have a 4.5" titanium plate holding my wrist together because there wasn't enough bone density remaining to heal without it - or even with a smaller plate.
    This is not a side effect I'm looking forward to seeing a whole lot more.

    1. Hi Cal. I'm actually taking PrEP as part of a study right now. I realize bone density loss is one of the side effects.
      Were you being monitored regularly by your doctor when taking this medication?
      In January they're going to scan my body to compare to how it was before I started the medication.
      I hope my results are not as bad as yours.
      Please update on your recovery.

  3. PREP has many adverse effects on the body and it is not a guarantee that you will not contract HIV. There are also STDs that can kill you, what about those? It is alarming that since the release of PREP, there is a trend of "Truvada sex parties" in NYC and other big cities. In these parties, gay men take PREP and have lots of unprotected sex. I know a man who contracted HIV while on PREP along with a nice package of other STDs. There was also a meningitis epidemic and syphilis is also a concern. Sorry to tell you that PREP is not going to save anyone from anything. If your mood, happiness or confidence improved because of PREP, then you need a psychologist, not a physician.

    1. Dude, these people live in a fantasy world where they believe they can take a magic pill and never contract an illness the rest of their lives. PrEP does not prevent infections like gonorrhea, chlamydia and hepatitis. Do these fools even think of that? No. Do they think of the side effects? No. They're actually on this site claiming that putting a synthetic, man-made substance in their body on a daily basis is making them "healthier than ever!" Morons.

  4. Carlos I am glad someone is atepping up and speaking out. That is just man-made stuff. There are Scabies, Crabs- pubic lice, Rectal Cancer and more. This Prep is just an excuse to have promiscuous sex. Irresponsible.

  5. Carlos I am glad someone is atepping up and speaking out. That is just man-made stuff. There are Scabies, Crabs- pubic lice, Rectal Cancer and more. This Prep is just an excuse to have promiscuous sex. Irresponsible.

    1. The only way to protect yourself from most of those is to not have sex. That isn't really an option for most humans on the planet. PrEP is quite a responsible choice. Nothing irresponsible about taking a pill every day, about going to the doc 4 times a year for HIV and STD screenings and medical monitoring. In fact - it is quite responsible. If you are against "man-made stuff" - you must also dislike condoms, birth control, cars, clothes, that roof over your head....



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